LunaseeStudios / Shutterstock.com Drain Opener Hazardous Waste LunaseeStudios / Shutterstock.com Don't Use in Toilets Unless the product is specifically designed for toilets, don’t use drain opener in one — it won’t work and may even damage a porcelain toilet. Ways to Reduce Try a Homemade Solution Before you use a heavy-duty drain cleaner, try a homemade solution made from less hazardous substances. Learn how to use baking soda and vinegar to clean and even unclog a drain.